Linezolid D3

An internal standard for the quantification of linezolid

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库存: 现货

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1mg

￥2400.00

1920.00

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5mg

￥5712.00

4570.00

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货号: ajcx30924
CAS: 1127120-38-0
别名: 利奈唑胺-D3,PNU-100766-d3
分子式: C16H17D3FN3O4
分子量: 340.36
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Linezolid-d₃ is intended for use as an internal standard for the quantification of linezolid by GC- or LC-MS. Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).¹ Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.² Formulations containing linezolid have been used to treat MRSA infections.

1.Ager, S., and Gould, K.Clinical update on linezolid in the treatment of gram-positive bacterial infectionsInfect. Drug Resist.587-102(2012) 2.Pauchard, L.A., Blot, M., Bruyere, T., et al.Linezolid and atorvastatin impact on pneumonia caused by Staphyloccocus aureus in rabbits with or without mechanical ventilationPLoS One12(11)e0187187(2017)