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- Mc-VC-PAB-SN38
Mc-VC-PAB-SN38
Mc-VC-PAB-SN38由可降解(cleavable)的ADClinker(Mc-VC-PAB)和SN38组成，SN38是一种DNA拓扑异构酶I抑制剂。Mc-VC-PAB-SN38可用于合成抗体偶联药物(ADC)。
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包装价格促销价数量
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5mg￥10575.008460.00- +
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10mg￥16025.0012820.00- +
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- 货号: ajcx31010
- CAS: 1801838-28-7
- 别名:
- 分子式: C51H58N8O13
- 分子量: 991.05
- 纯度: ＞98%
- 溶解度: DMSO: 28.57 mg/mL (28.83 mM)
- 储存: -20°C, stored under nitrogen
- 库存: 现货
Background
Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
