Methyl brevifolincarboxylate

Methylbrevifolincarboxylate(Brevifolincarboxylicacidmethylester)是一种有效的流感病毒PB2帽结合抑制剂。Methylbrevifolincarboxylate对流感病毒A/PuertoRico/8/34(H1N1)和A/Aichi/2/68(H3N2)具有抑制作用，IC50值分别为27.16μM和33.41μM。具有抗氧化活性。

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Background

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM. Anti-oxidant activity[1][2].

Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC50 value of 8.9 μM.

[1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. [2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340.