MSAB
MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
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包装价格促销价数量
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5mg￥925.00740.00- +
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10mg￥1625.001300.00- +
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25mg￥3262.002610.00- +
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50mg￥4850.003880.00- +
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100mg￥7337.005870.00- +
- 货号: ajcx31120
- CAS: 173436-66-3
- 别名:
- 分子式: C15H15NO4S
- 分子量: 305.35
- 纯度: ＞98%
- 溶解度: DMSO: 250 mg/mL (818.73 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
MSAB impedes RAW264.7 cells and human PMBCs differentiating into OCs. MSAB decreases the expression of β‐catenin in RAW264.7 and ARP1 WT cells.[2]
MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in xenograft mice and MMTV-Wnt1 transgenic mice.[3]
[1] So-Young Hwang, et al. Cell Rep. 2016 Jun 28;16(1):28-36. [2] Zhang Y, et al. Clin Transl Med. 2022 Feb;12(2):e684.
