MSN-125

MSN-125是有效的Bax和Bak低聚抑制剂。MSN-125可防止线粒体外膜通透性(MOMP)，IC50为4μM。MSN-125有效抑制HCT-116，BMK细胞和原代皮层神经元中Bax/Bak介导的凋亡，保护原代神经元免受谷氨酸兴奋性毒性。

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库存: 现货

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5mg

￥10250.00

8200.00

- +
10mg

￥17625.00

14100.00

- +
25mg

￥36862.00

29490.00

- +
50mg

￥58775.00

47020.00

- +

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Background

MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].

MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].

[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell?Chem Biol. 2017 Apr 20;24(4):493-506.e5.