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NH2-PEG7是一种PROTAClinker(PROTAClinker),属于PEG类。NH2-PEG7可用于PROTACPARP1降解剂iRucaparib-AP6的合成。
NH2-PEG7 is a PROTAC linker, which refers to the PEG composition. NH2-PEG7 can be used in the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6[1].
[1]. Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231.
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