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- PKC (Protein kinase C)
- O-Desmethyl Midostaurin-d5
O-Desmethyl Midostaurin-d5
O-DesmethylPKC412-d5(CGP62221-d5)是O-DesmethylPKC412的氘代物。O-DesmethylMidostaurin(CGP62221;O-DesmethylPKC412)是Midostaurin的活性代谢物，通过细胞色素P450肝酶代谢产生，可以作为Midostaurin在体内代谢的指标之一。
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1mg￥11337.009070.00- +
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- 货号: ajcx31228
- CAS: N/A
- 别名: CGP62221-d5; O-Desmethyl PKC412-d5
- 分子式: C34H23D5N4O4
- 分子量: 561.64
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
O-Desmethyl PKC412-d5 (CGP62221-d5) is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism[1].
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.
