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- Angiotensin Receptor
- Olmesartan methyl ester
Olmesartan methyl ester
Olmesartanmethylester是Olmesartanmedoxomil合成的中间体。Olmesartanmedoxomil是一种有效的选择性的血管紧张素(angiotensinAT1)受体拮抗剂，IC50为66.2μM。
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包装价格促销价数量
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1mg￥1300.001040.00- +
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5mg￥3775.003020.00- +
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- 货号: ajcx31240
- CAS: 1347262-29-6
- 别名: 奥美沙坦甲酯
- 分子式: C25H28N6O3
- 分子量: 460.53
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM[1][2].
[1]. Dimitrios Ntountaniotis, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism. Comb Chem High Throughput Screen. 2014;17(8):652-62. [2]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9.
