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Omidenepag是OmidenepagIsopropyl的药理活性形式,是一种选择性的非前列腺素EP2受体激动剂,EC50为1.1nM。Omidenepag对h-EP2的结合亲和力(IC50)为10nM。
Omidenepag,a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC50 of 1.1 nM. Omidenepag shows binding affinities (IC50) 10 nM for h-EP2[1].
[1]. Iwamura R, et al. Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl. J Med Chem. 2018 Aug 9;61(15):6869-6891.
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