PF-06426779是一种有效的和选择性的白介素-1受体相关激酶4(IRAK4)抑制剂，IC50值为0.3nM。
货号:ajcx31282
CAS:1817628-40-2
分子式:C17H18FN3O4
分子量：347.34
溶解度:DMSO: 250 mg/mL (719.76 mM); H2O: < 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货
Background:
PF-06426779 is a potent and selective inhibitor of interleukin?1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1].
PF-06426779 inhibits IRAK4, with an IC50 of 12.7 nM in the peripheral blood mononuclear cells (PBMCs) assay[1].
[1]. Lee KL, et, al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13; 60(13): 5521-5542.
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