Phosphoramide mustard (cyclohexanamine)

An alkylating agent and active metabolite of cyclophosphamide

原价

￥3662-6475

价格

￥ 2930-5180

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产品引用

货号: ajcx31294
CAS: 1566-15-0
别名: NSC 69945, PMC
分子式: C10H24Cl2N3O2P
分子量: 320.2
纯度: >98%
溶解度: DMSO : 10 mg/mL, aqueous solution is slowly hydrolyzed, ready to use
储存: Store at -20°C, protect from light, stored under nitrogen
库存: 现货

Background

Phosphoramide mustard is an alkylating agent and active metabolite of cyclophosphamide .¹ It is formed from cyclophosphamide via the ring-opened tautomer of the cytochrome P450 (CYP) isoform-formed intermediate 4-hydroxycyclophosphamide.² Phosphoramide mustard induces DNA crosslinking, alkylates guanine in DNA, and increases the production of covalent DNA-protein conjugates in, and is cytotoxic to, HT-1080 human fibrosarcoma cells in a concentration-dependent manner. It is toxic to adult mice and teratogenic to embryos when administered to pregnant dams at a dose of 154 mg/kg on day 11 of gestation.³

1.Groehler, A., IV, Villalta, P.W., Campbell, C., et al.Covalent DNA-protein cross-linking by phosphoramide mustard and nornitrogen mustard in human cellsChem. Res. Toxicol.29(2)190-202(2016) 2.Huitema, A.D., Math?t, R.A., Tibben, M.M., et al.A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamideJ. Pharmacokinetic. Pharmacodyn.28(3)211-230(2001) 3.Gibson, J.E., and Becker, B.A.Teratogenicity of structural truncates of cyclophosphamide in miceTeratology4(2)141-150(1971)

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Phosphoramide mustard (cyclohexanamine)

Phosphoramide mustard (cyclohexanamine)详情

Background