Pomalidomide-PEG1-C2-N3
Pomalidomide-PEG1-C2-N3是一种合成的E3连接酶配体-linker偶联物，包含基于Pomalidomide的cereblon配体和1个单元PEG的linker。Pomalidomide-PEG1-C2-N3可通过PROTAC技术合成选择性的CDK6降解剂CP-10。CP-10诱导CDK6降解，DC50为2.1nM。
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100mg￥10575.008460.00- +
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- 货号: ajcx31326
- CAS: 2271036-44-1
- 别名: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50
- 分子式: C17H18N6O5
- 分子量: 386.36
- 纯度: ＞98%
- 溶解度:
- 储存: -20°C, stored under nitrogen
- 库存: 现货
Background
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
