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Propargyl-PEG2-amine
Propargyl-PEG2-amine是一种不可降解(non-cleavable)的ADClinker，用于抗体偶联药物(ADCs)的合成。Propargyl-PEG2-amine是一种PROTAClinker，属于PEG类。Propargyl-PEG2-NH2可用于合成一系列PROTAC分子。
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包装价格促销价数量
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100mg￥375.00300.00- +
- 货号: ajcx31340
- CAS: 944561-44-8
- 别名: 2-(2-(丙-2-炔-1-基氧基)乙氧基)乙胺
- 分子式: C7H13NO2
- 分子量: 143.18
- 纯度: ＞98%
- 溶解度:
- 储存: 4°C, protect from light, stored under nitrogen
- 库存: 现货
Background
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A. [2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.
