PROTAC BRD4 Degrader-5
PROTACBRD4Degrader-5是一种基于PROTAC的BRD4降解剂，可有效降解HER2阳性和阴性乳腺癌细胞系中的BRD4。
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包装价格促销价数量
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10mg￥13887.0011110.00- +
- 货号: ajcx31348
- CAS: 2409538-70-9
- 别名:
- 分子式: C50H62ClN9O8S2
- 分子量: 1016.67
- 纯度: ＞98%
- 溶解度: DMSO: 145 mg/mL (142.62 mM); Water: < 0.1 mg/mL (insoluble)
- 储存: Store at -20°C
- 库存: 现货
Background
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1]. Western Blot Analysis[1] Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells
[1]. Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.
