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PROTACBRD4Degrader-5-CO-PEG3-N3(Compound2)一种用于PAC的PROTAC-linker偶联物,包含BRD4降解剂GNE-987和3个PEG的linker。
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker[1].
[1]. Mar? A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.
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