Rotundifuran是一种从Vitexrotundifolia中分离的拉丹烷型二萜。Rotundifuran能够抑制人骨髓白血病细胞的细胞周期进程并诱导细胞凋亡。
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Rotundifuran, a labdane type diterpene, is isolated from Vitex rotundifolia. Rotundifuran can inhibit the cell cycle progression and induce apoptosis in human myeloid leukaemia cells[1][2].
[1]. Ko WG, et, al. Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells. Phytother Res. 2001 Sep; 15(6):535-7. [2]. Li WX, et, al. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res. 2005 Apr; 7(2): 95-105.