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S-(1-Hydroxy-2-methylpropan-2-yl)methanesulfonothioate是一种谷胱甘肽可降解(cleavable)的ADClinker,用于抗体偶联药物(ADCs),属于Alkyl-Chain类,是ADCs用于mAb附着的连接体部分。
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1].
[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
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