A polyphenol flavonoid with diverse biological activities
Salvigenin is a polyphenol flavonoid originally found in Alnus japonica with diverse biological activities.1,2,3 It inhibits hydrogen peroxide-induced apoptosis and reduces the generation of reactive oxygen species (ROS) in SH-SY5Y human neuroblastoma cells when used at a concentration of 25 ?M.2 Salvigenin (25 and 50 ?M) decreases cleaved caspase-3 levels and the Bax/B cell lymphoma 2 (Bcl-2) ratio in SH-SY5Y cells. It reduces the viability of MCF-7 human breast cancer cells in a concentration-dependent manner.3 Salvigenin (3.65-9.68 ?g/mouse per day) enhances the delayed-type hypersensitivity (DTH) response to sheep red blood cells in mice. It increases the production of IFN-γ induced by lysate antigens in isolated mouse splenocytes. Salvigenin (9.68 ?g/mouse per day) reduces tumor growth in a spontaneous mouse mammary tumor (SMMT) model.
1.Wollenweber, E.Flavonoids from Alnus crispa, A. japonica, A. koehnei and A. sinuataPhytochemistry13(10)2318-2319(1974) 2.Rafatian, G., Khodagholi, F., Farimani, M.M., et al.Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H2O2Mol. Cell. Biochem.371(1-2)9-22(2012) 3.Noori, S., Hassan, Z.M., Yaghmaei, B., et al.Antitumor and immunomodulatory effects of salvigenin on tumor bearing miceCell. Immunol.286(1-2)16-21(2013)
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