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Sandacanol是嗅觉受体(OR10H1)的特异性激动剂。Sandacanol诱导膀胱癌细胞发生细胞周期停滞和凋亡(apoptosis)。
Sandacanol is a specific agonist of olfactory receptor (OR10H1). Sandacanol induces cell cycle arrest and some apoptosis in bladder cancer cells[1].
Sandacanol (50, 100, 300, 500, and 700 μM; 24 or 48 h) treatment significantly diminishes cell viability, cell proliferation and migration and induces a limited degree of apoptosis in BFTC905 bladder cancer cells[1].
[1]. Lea Weber, et al. Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer. Front Physiol. 2018 May 16;9:456.
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