SIRT1-IN-1是一种选择性SIRT1抑制剂，IC50为0.205μM。SIRT1-IN-1抑制SIRT2，IC50为11.5μM。SIRT1-IN-1是一种吲哚，是巨细胞病毒(CMV)抑制剂，具有抗病毒活性。
SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2].
SIRT1-IN-1 (compound 2) has little effect on SIRT3 (IC50>100 μM) and HDAC (IC50>100 μM)[1].
[1]. Andrew D Napper, et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. [2]. Thomas Shenk, et al. Sirtuin Modulators as Inhibitors of Cytomegalovirus. US20160296523A1.
动态评分
0.0