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  • SJF620
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SJF620

SJF620是一种PROTACBTK降解剂,DC50为7.9nM。SJF620含有Lenalidomide类似物,可募集CRBN。

原价
¥6262-20300
价格
5010-16240
SJF620的二维码

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  • 库存: 现货
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  • 货号: ajcx31476
  • CAS: 2376187-16-3
  • 别名:
  • 分子式: C41H44N8O7
  • 分子量: 760.84
  • 纯度: >98%
  • 溶解度: DMSO: 100 mg/mL (131.43 mM)
  • 储存: -20°C, stored under nitrogen
  • 库存: 现货

Background

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].


SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].


SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].


[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

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