SJF620

SJF620是一种PROTACBTK降解剂，DC50为7.9nM。SJF620含有Lenalidomide类似物，可募集CRBN。

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库存: 现货

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数量
5mg

￥6262.00

5010.00

- +
10mg

￥10575.00

8460.00

- +
25mg

￥20300.00

16240.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.