SKF-83566
A dopamine D1 receptor antagonist
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包装价格促销价数量
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5mg￥1037.00830.00- +
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10mg￥1625.001300.00- +
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25mg￥2937.002350.00- +
- 货号: ajcx31478
- CAS: 99295-33-7
- 别名:
- 分子式: C17H18BrNO
- 分子量: 332.23
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
SKF 83566 is a dopamine D1 receptor antagonist.1,2,3 In vivo, SKF 83566 (0.005, 0.01, and 0.03 mg/kg) reduces dexbenzetimide- and scopolamine-induced locomotor stereotypy in rats.1 It decreases ghrelin-induced increases in novel object exploration and food intake in rats when administered at a dose of 100 ?g/kg.2 SKF 83566 also reduces schedule-induced polydipsia in rats.3
1.Fritts, M.E., Mueller, K., and Morris, L.Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiridePharmacol. Biochem. Behav.60(3)639-644(1998) 2.Jacoby, S.M., and Currie, P.J.SKF 83566 attenuates the effects of ghrelin on performance in the object location memory taskNeurosci. Lett.504(3)316-320(2011) 3.Mittleman, G., Rosner, A.L., and Schaub, C.L.Polydipsia and dopamine: Behavioral effects of dopamine D1 and D2 receptor agonists and antagonistsJ. Pharmacol. Exp. Ther.271(2)638-650(1994)
