A macrolide antibiotic
Tylvalosin is a macrolide antibiotic.1 It is active against S. aureus, E. coli, and P. multocida (MICs = 2, 128, and 128 ?g/ml, respectively). Tylvalosin (5 and 10 ?g/ml) reduces LPS-induced production of pro-inflammatory cytokines, prostaglandin E2 , and nitric oxide in RAW 264.7 cells.2 It reduces the severity of lung lesions in pigs infected with M. hyopneumoniae and P. multocida when administered at a dose of 10 mg/kg per day in the drinking water.3 Formulations containing tylvalosin have been used in the treatment and metaphylaxis of enzootic pneumonia caused by M. hyopneumoniae in pigs.
1.Yang, B., Lei, Z., Zhao, Y., et al.Combination susceptibility testing of common antimicrobials in vitro and the effects of sub-MIC of antimicrobials on Staphylococcus aureus biofilm formationFront. Microbiol.82125(2017) 2.Zhao, Z., Tang, X., Zhao, X., et al.Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activationBiochem. Pharmacol.90(1)73-87(2014) 3.Lopez Rodriguez, A., Berge, A.C., Ramage, C., et al.Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigsPorcine Health Manag.6(1)39(2020)
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