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VenetoclaxN-oxide是Venetoclax的杂质。Venetoclax(ABT-199;GDC-0199)是一种高效,选择性的和口服有效的Bcl-2抑制剂,Ki小于0.01nM。
Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM[1].
[1]. Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8.
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