ZZW-115 hydrochloride
A NUPR1 inhibitor
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包装价格促销价数量
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1mg￥1037.00830.00- +
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5mg￥2725.002180.00- +
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10mg￥4100.003280.00- +
- 货号: ajcx31688
- CAS: 10122-45-9
- 别名:
- 分子式: C24H34Cl3F3N4S
- 分子量: 573.97
- 纯度: ＞98%
- 溶解度: Water: 100 mg/mL (174.23 mM)
- 储存: 4°C, stored under nitroge
- 库存: 现货
Background
ZZW-115 is an inhibitor of nuclear protein 1 (NUPR1).1 It binds to NUPR1 (Kd = 2.1 ?M) in a cell-free assay. ZZW-115 is cytotoxic against a panel of 11 pancreatic ductal adenocarcinoma cell lines (IC50s = 0.84-4.93 ?M), as well as against a panel of 16 additional cancer cell lines, including glioblastoma, lymphoma, and leukemia cells (IC50s =0.25-7.75 ?M). It induces apoptosis and necrosis in MiaPaCa-2, LIPC, Foie8b, 02-063, and HN14 pancreatic cancer cells when used at concentrations of 3 and 5 ?M. ZZW-115 induces accumulation of reactive oxygen species (ROS), lipid peroxidation, and ferroptosis in MiaPaCa-2 cells in a concentration-dependent manner.2 It reduces tumor growth in a MiaPaCa-2 mouse xenograft model when administered at doses of 1, 2.5, or 5 mg/kg.1
1.Santofimia-Casta?o, P., Xia, Y., Lan, W., et al.Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosisJ. Clin. Invest.129(6)2500-2513(2019) 2.Huang, C., Santofimia-Casta?o, P., Liu, X., et al.NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent mannerCell Death Discov.7(1)269(2021)
