NH2-PEG5-OH

NH2-PEG5-OH是一种PROTAClinker，属于PEG类。NH2-PEG5-OH可用于合成PROTAC分子。NH2-PEG5-OH也是一种不可降解(non-cleavable)的含5个单元PEG的ADClinker，可用于合成抗体偶联药物(ADC)。

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库存: 现货

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数量
100mg

￥612.00

490.00

- +
500mg

￥1212.00

970.00

- +

已选 0 种 0 瓶

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Background

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.