Zingiberene(α-Zingiberene)是一种单环倍半萜烯，是姜油的主要成分。具有神经保护潜能。Zingiberene能诱导自噬(autophagy)。具有抗癌活性。
Zingiberene (α-Zingiberene) is a monocyclic sesquiterpene which is the predominant constituent of ginger with oil content (Zingiber officinale). Neuroprotective potential[1]. Zingiberene triggers autophagy. Anticancer activity[2].
Zingiberene (6.25, 12.5, 25, 50 and 100 μg/mL; 24 hours) attenuates hydrogen peroxide-induced toxicity in neuronal cells[1]. Zingiberene (0, 10, 20 and 40 µM; 24 hours) considerably inhibits the proliferation of Colon cancer (CC) cells[2].
[1]. B Togar, et al. Zingiberene attenuates hydrogen peroxide-induced toxicity in neuronal cells. Hum Exp Toxicol. 2015 Feb;34(2):135-44. [2]. Hai Chen, Zingiberene inhibits in vitro and in vivo human colon cancer cell growth via autophagy induction, suppression of PI3K/AKT/mTOR Pathway and caspase 2 deactivation. J BUON. Jul-Aug 2019;24(4):1470-1475.
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