Coclaurine

A benzylisoquinoline alkaloid with nAChR inhibitory and insecticidal activities

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5mg

￥4500.00

3600.00

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货号: ajcx31848
CAS: 486-39-5
别名: 衡州乌药碱,(+)-(R)-Coclaurine; (R)-Coclaurine; d-Coclaurine
分子式: C17H19NO3
分子量: 285.34
纯度: >98%
溶解度:
储存: Store at -20°C
库存: 现货

Background

Coclaurine is a benzylisoquinoline alkaloid that has been found in T. quinquenervia and has nicotinic acetylcholine receptor (nAChR) inhibitory and insecticidal activities.^1,2 It inhibits ACh-induced currents in Xenopus oocytes expressing human α4β2 or α4β4 subunit-containing nAChRs (IC₅₀s = 49 and 18 ?M, respectively).¹ Coclaurine induces mortality in D. melanogaster and C. pomonella larvae (LD50s = 78.2 and 35.4 ?g/ml, respectively).²

1.Exley, R., Iturriaga-Vásquez, P., Lukas, R.J., et al.Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptorsBr. J. Pharmacol.146(1)15-24(2005) 2.Quiroz-Carre?o, S., Pastene-Navarrete, E., Espinoza-Pinochet, C., et al.Assessment of insecticidal activity of benzylisoquinoline alkaloids from Chilean Rhamnaceae plants against fruit-fly Drosophila melanogaster and the lepidopteran crop pest Cydia pomonellaMolecules25(21)5094(2020)