Angiopep-2 hydrochloride
Angiopep-2hydrochloride是脑肽载体。抗肿瘤药物与Angiopep-2肽载体的结合可提高其在脑癌中的活性.
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包装价格促销价数量
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1mg￥1525.001220.00- +
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5mg￥4312.003450.00- +
- 货号: ajcx31852
- CAS: N/A
- 别名:
- 分子式: C104H150ClN29O31
- 分子量: 2337.93
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer[1].
Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel- Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar to that of paclitaxel against human cancer cell lines[1].
ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells[1].
[1]. A Régina, et al. Antitumour Activity of ANG1005, a Conjugate Between Paclitaxel and the New Brain Delivery Vector Angiopep-2. Br J Pharmacol. 2008 Sep;155(2):185-97.
