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  • PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4 TFA的可视化放大

PROTAC AR Degrader-4 TFA

PROTACARDegrader-4包含cIAP1配体结合基团,linker和雄激素受体(AR)配体结合基团。基于cIAP1的降解剂也被称为SNIPER。

原价
¥15487-15487
价格
12390-12390
PROTAC AR Degrader-4 TFA的二维码

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  • 库存: 现货
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  • 货号: ajcx31856
  • CAS: N/A
  • 别名:
  • 分子式: C45H68F3N3O11
  • 分子量: 884.03
  • 纯度: >98%
  • 溶解度: DMSO: 200 mg/mL (226.24 mM)
  • 储存: Store at -80°C
  • 库存: 现货

Background

PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].


Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure. Targeting proteins for degradation involves three steps. 1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein. 2, the target protein is polyubiquitinated by IAPs. 3, the polyubiquitinated protein is degraded by proteasome.


[1]. Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.

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