GAKinhibitor49hydrochloride是一种ATP竞争性的、高选择性细胞周期蛋白G相关激酶(GAK)抑制剂，Ki为0.54nM，细胞IC50为56nM。GAKinhibitor49hydrochloride也显示与RIPK2结合。
GAK inhibitor 49 hydrochloride is a potent, ATP-competitive and highly selective cyclin G associated kinase (GAK) inhibitor with a Ki of 0.54 nM and a cell IC50 of 56 nM. GAK inhibitor 49 hydrochloride also shows binding to RIPK2[1].
GAK inhibitor 49 (compound 49) hydrochloride shows a weak inhibitory effect on AAK1, BMP2K and STK16, with IC50s of 28, 63 and >100μM, respectively[1].
[1]. Asquith CRM, et al. Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem. 2018;13(1):48-66.
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