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- Methyltetrazine-PEG4-maleimide
Methyltetrazine-PEG4-maleimide
Methyltetrazine-PEG4-maleimide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
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包装价格促销价数量
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10mg￥2175.001740.00- +
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25mg￥3775.003020.00- +
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100mg￥9712.007770.00- +
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- 货号: ajcx31910
- CAS: 1802908-02-6
- 别名:
- 分子式: C24H30N6O7
- 分子量: 514.53
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
