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- PKD (Protein kinase D)
- PKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA
A synthetic peptide inhibitor of PKA
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包装价格促销价数量
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5mg￥2287.001830.00- +
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10mg￥3775.003020.00- +
- 货号: ajcx31914
- CAS: N/A
- 别名: PKI-(6-22)-amide TFA
- 分子式: C82H131F3N28O26
- 分子量: 1982.08
- 纯度: ＞98%
- 溶解度: Water: 50 mg/mL (25.23 mM)
- 储存: -20°C, away from moisture
- 库存: 现货
Background
PKA inhibitor fragment (6-22) amide is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA; Ki = 1.7 nM) derived from the heat-stable PKA inhibitor protein PKI.1 It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Both the arginine-containing pseudosubstrate site of the PKI peptide in its COOH terminus and the residue Phe10 in NH2-terminal portion are required for this high affinity binding.2
1.Glass, D.B., Cheng, H.C., Mende-Mueller, L., et al.Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor proteinJ. Biol. Chem.264(15)8802-8810(1989) 2.Glass, D.B., Lundquist, L.J., Katz, B.M., et al.Protein kinase inhibitor-(6-22)-amide peptide analogs with standard and nonstandard amino acid substitutions for phenylalanine 10. Inhibition of cAMP-dependent protein kinaseJ. Biol. Chem.264(24)14579-14584(1989)
