An SHP-1 activator
SC-43 is an activator of Src homology region 2 domain-containing phosphatase 1 (SHP-1).1 It activates SHP-1 phosphatase activity in a cell-free assay and inhibits IL-6-induced phosphorylation of STAT3 in PLC/PRF/5 hepatocellular carcinoma cells when used at a concentration of 10 ?M. SC-43 inhibits the proliferation of PLC/PRF/5 cells (IC50 = 0.5 ?M). It decreases disease severity and improves survival in a mouse model of carbon tetrachloride-induced liver fibrosis when administered at doses of 10 and 20 mg/kg.2
1.Chen, K.-F., Tai, W.-T., Hsu, C.-Y., et al.Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activityEur. J. Med. Chem.55220-227(2012) 2.Su, T.-H., Shiau, C.-W., Jao, P., et al.Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosisSci. Rep.7(1)1728(2017)
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