Lats-IN-1

An inhibitor of LATS1 and LATS2

原价

￥1962-5425

价格

￥ 1570-4340

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产品引用

Cell.Cell host & microbe.November 8, 2023
Cell . MOLECULAR PLANT . 1 February 2023
Cell . Immunity . August 10, 2021
Nature Communications.1413 (2022)
ACS . Nano Lett . April 10, 2023

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Background

LATS-IN-1 is an inhibitor of large tumor suppressor kinase 1 (LATS1) and LATS2 (IC₅₀ = 2 nM for both), key regulators of Hippo regenerative signaling.¹ It inhibits phosphorylation of YES1-associated transcriptional regulator (YAP1) in serum-starved HEK293A cells (EC₅₀ = 510 nM). LATS-IN-1 (10 ?M) increases the proliferation of Müller glial cells and isolated mouse cardiomyocytes.

1.Kastan, N., Gnedeva, K., Alisch, T., et al.Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissuesNat. Commun.12(1)3100(2021)

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生命科学

有机化学

无机化学

材料科学

Lats-IN-1

Lats-IN-1详情

Background