- 首页
- HSP (Heat shock proteins)
- Aminohexylgeldanamycin
Aminohexylgeldanamycin
Aminohexylgeldanamycin(AHGDM)，Geldanamycin的衍生物，是一种热休克蛋白90(HSP90)抑制剂。Aminohexylgeldanamycin具有抗血管生成和抗肿瘤活性。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥3262.002610.00- +
-
10mg￥5175.004140.00- +
-
25mg￥10250.008200.00- +
- 货号: ajcx32014
- CAS: 485395-71-9
- 别名: AHGDM
- 分子式: C34H52N4O8
- 分子量: 644.8
- 纯度: ＞98%
- 溶解度: DMSO: 200 mg/mL (310.17 mM)
- 储存: -20°C, protect from light
- 库存: 现货
Background
Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1].
HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].
[1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270. [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.
