Endothelin-2 (49-69), human TFA

Endothelin-2(49-69),human(TFA)(Endothelin-2(49-69)(human,canine)(TFA))是由21个氨基酸组成的血管活性肽，可与G蛋白连接的跨膜受体，ET-RA和ET-RB结合。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥3387.00

2710.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx32030
CAS: N/A
别名: Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA
分子式: C117H161N26F3O34S4
分子量: 2660.94
纯度: >98%
溶解度:
储存: -20°C, protect from light
库存: 现货

Background

Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM)[1]. Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia[2].

Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr[1].

[1]. Grimshaw MJ, et al. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol. 2002 Sep;32(9):2393-400.