L-690330 hydrate

L-690330hydrate是一种竞争性的肌醇单磷酸酶(inositolmonophosphatase(IMPase))抑制剂，对重组人和牛IMPase的Ki值为0.27μM和0.19μM，对人和牛前脑皮层IMPase的为Ki值为0.30μM和0.42μM。L-690330hydrate对其敏感性是大鼠和小鼠的IMPase的10倍。

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5mg

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货号: ajcx32042
CAS: N/A
别名:
分子式: C8H14O9P2
分子量: 316.14
纯度: >98%
溶解度: Water: 31 mg/mL (98.06 mM); DMSO: 31 mg/mL (98.06 mM)
储存: Store at -20°C
库存: 现货

Background

L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase[1].

L-690330 hydrate (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells[2].

L-690330 hydrate (intracerebroventricular injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test[3]. Animal Model: Eight-week-old male ICR mice[3]

[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. [2]. Cárdenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83. [3]. Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8.