- 首页
- HSP (Heat shock proteins)
- 3-Phenyltoxoflavin
3-Phenyltoxoflavin
3-Phenyltoxoflavin是Toxoflavin的衍生物，是一种Hsp90抑制剂，抑制Hsp90-TPR2A之间相互作用的Kd值为585nM。3-Phenyltoxoflavin具有抗癌活性。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥3262.002610.00- +
-
10mg￥5400.004320.00- +
-
25mg￥10575.008460.00- +
-
50mg￥16562.0013250.00- +
-
100mg￥25112.0020090.00- +
- 货号: ajcx32050
- CAS: 32502-63-9
- 别名:
- 分子式: C13H11N5O2
- 分子量: 269.26
- 纯度: ＞98%
- 溶解度: DMSO: 7.14 mg/mL (26.52 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].
3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1].3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].
[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54. [2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.
