PHPS1 sodium

A selective SHP-2 inhibitor

原价

￥4100-4100

价格

￥ 3280-3280

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产品引用

Cell.Cell host & microbe.November 8, 2023
Cell . MOLECULAR PLANT . 1 February 2023
Cell . Immunity . August 10, 2021
Nature Communications.1413 (2022)
ACS . Nano Lett . April 10, 2023

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Background

PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC₅₀ = 2.1 ?M; K_i = 0.73 ?M).¹ It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC₅₀s = 5.4, 19, 30, and 39 ?M, respectively).¹ PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.¹

1.Hellmuth, K., Grosskopf, S., Lum, C.T., et al.Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput dockingProc. Natl. Acad. Sci. USA105(20)7275-7280(2008)

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PHPS1 sodium

PHPS1 sodium详情

Background