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- Keap1-Nrf2
- CBR-470-2
CBR-470-2
CBR-470-2是甘氨酸取代的类似物，可以激活NRF2信号传导。CBR-470-2可用于调节糖酵解。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥5175.004140.00- +
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10mg￥8637.006910.00- +
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25mg￥16562.0013250.00- +
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50mg￥25650.0020520.00- +
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100mg￥37400.0029920.00- +
- 货号: ajcx32154
- CAS: 2416095-00-4
- 别名:
- 分子式: C12H13Cl2NO6S2
- 分子量: 402.27
- 纯度: ＞98%
- 溶解度: DMSO: 200 mg/mL (497.18 mM)
- 储存: 4°C, stored under nitrogen
- 库存: 现货
Background
CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis[1].
CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].
CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1]. Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]
[1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604.
