A tyrosinase inhibitor
3-O-ethyl-L-Ascorbic acid is an inhibitor of tyrosinase (IC50s = 16.65 and 29.69 mM for the human and mushroom enzymes, respectively).1,2 It also scavenges DPPH radicals (IC50 = 0.032 g/L).2 Formulations containing 3-O-ethyl-L-ascorbic acid have been used in cosmetic products as skin-lightening agents.
1.Jeon, S.-H., Kim, K.-H., Koh, J.-U., et al.Inhibitory effects on L-dopa oxidation of tyrosinase by skin-whitening agentsBull. Korean Chem. Soc.26(7)1135-1137(2005) 2.Liao, W.C., Huang, Y.-T., Lu, L.-P., et al.Antioxidant ability and stability studies of 3-O-ethyl ascorbic acid, a cosmetic tyrosinase inhibitorJ. Cosmet. Sci.69(4)233-243(2018)
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