2,6-Dimethylquinoline
2,6-Dimethylquinoline是一种来自Peucedantupraeruptorum根的天然成分，是CYP1A2的抑制剂，IC50为3.3µM。2,6-Dimethylquinoline也抑制CYP2B6的活性，IC50为480µM。
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包装价格促销价数量
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500mg￥550.00440.00- +
- 货号: ajcx32326
- CAS: 877-43-0
- 别名: 2,6-二甲基喹啉
- 分子式: C11H11N
- 分子量: 157.22
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM. 2,6-Dimethylquinoline also inhibits CYP2B6 activity with an IC50 of 480 µM[1][2][3].
[1]. Laura E Korhonen, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15. [2]. L E Korhonen, et al. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. Br J Pharmacol. 2007 Apr;150(7):932-42. [3]. Cun Zhang, et al. Studies on chemical constituents from roots of Peucedanum praeruptorum II. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(16):1333-5.
