5-A-RU-PABC-Val-Cit-Fmoc

5-A-RU-PABC-Val-Cit-Fmoc是5-A-RU的前药。5-A-RU是细菌核黄素的前体，是一种粘膜相关的不变T(MAIT)细胞激活剂。5-A-RU通过与来自其他代谢途径的小分子（如乙二醛和甲基乙二醛）的非酶反应形成有效的MAIT激活抗原。

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1mg

￥2612.00

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Background

5-A-RU-PABC-Val-Cit-Fmoc is the prodrug of 5-A-RU[1]. 5-A-RU, a precursor of bacterial Riboflavin, is a mucosal-associated invariant T (MAIT) cells activator. 5-A-RU forms potent MAIT-activating antigens via non-enzymatic reactions with small molecules, such as glyoxal and methylglyoxal, which are derived from other metabolic pathways[2][3][4].

When added to MAIT cell cultures, 5-A-RU-PABC-Val-Cit-Fmoc (Compound 10) induces higher levels of mucosal-associated invariant T (MAIT) cell activation than 5-A-RU alone[1].

[1]. Joshua Lange, et al. The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes. ACS Chem Biol. 2020 Feb 21;15(2):437-445. [2]. Corbett AJ, et al. T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature. 2014 May 15;509(7500):361-5. [3]. Eckle SB, et al. Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells. J Biol Chem. 2015 Dec 18;290(51):30204-11. [4]. Soudais C, et al. In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin PrecursorDerivatives Activating Mouse MAIT Cells. J Immunol. 2015 May 15;194(10):4641-9.