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  • HS-27
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HS-27

HS-27,一种荧光Hsp90抑制剂,检测完整组织标本表面Hsp90的表达。HS-27由SNX-5422的核心元素组成,SNX-5422是一种Hsp90抑制剂,通过PEG连接物与荧光素衍生物(异硫氰酸荧光素或FITC)连接,后者与外周表达的Hsp90结合。HS-27在乳腺癌的观察与研究中有潜在的应用。

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¥3775-26712
价格
3020-21370
HS-27的二维码

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  • 库存: 现货
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  • 货号: ajcx32448
  • CAS: 1562024-11-6
  • 别名:
  • 分子式: C52H60N6O12S
  • 分子量: 993.13
  • 纯度: >98%
  • 溶解度: DMSO: 125 mg/mL (125.86 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer[1].


HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. HS-27 fluorescence is greater in tumor than non-tumor tissue[1].


[1]. Crouch BT, et al. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Sci Rep. 2019 Mar 5;9(1):3461.

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