Practolol

Practolol是一种有效和选择性的β1肾上腺素能受体拮抗剂。Practolol可用于心律失常的研究。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥762.00

610.00

- +
25mg

￥1300.00

1040.00

- +
50mg

￥2175.00

1740.00

- +
100mg

￥3262.00

2610.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

Practolol (10 μM; 30 min) preferentially antagonizes the relaxant effects produced by R0363 in spontaneously contracted tracheal preparations from the guinea-pig[1].Practolol (10 nM-100 μM) blocks the progesterone production induced by (-)epinephrine in a dose-dependent manner in granulosa cells[2].

Practolol (0.5 mg/kg; i.v.) decreases heart rate, left ventricular dP/dt max, myocardial blood flow and cardiac output in intact close-chest dogs[3].Practolol (0.5 mg/kg; i.v.) decreases normal myocardial blood flow but flow in the ischaemic area remains unchanged after coronary artery ligation[3].

[1]. Iakovidis D, et, al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85. [2]. Adashi EY, et, al. Stimulation of beta 2-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo. Endocrinology. 1981 Jun;108(6):2170-8. [3]. Marshall RJ, et, al. Comparative effects of propranolol and practolol in the early stages of experimental canine myocardial infarction. Br J Pharmacol. 1976 Jun;57(2):295-303.