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  • Cyclic ADP-ribose ammonium
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Cyclic ADP-ribose ammonium

An endogenous Ca2+ mobilizer

原价
¥7775-7775
价格
6220-6220
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  • 库存: 现货
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  • 货号: ajcx32462
  • CAS: N/A
  • 别名: cADPR ammonium
  • 分子式: C15H21N5O13P2.X(NH3)
  • 分子量:
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.1,2,3,4,5 This second messenger is generated via the cADP-ribose synthases CD38 and CD157.6,5,7 cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.8 In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with isoproterenol , and treatment with this metabolite at 100 ?M under heat stress conditions induces the release of oxytocin from the mouse hypothalamus.9,4


1.Lee, H.C., Walseth, T.F., Bratt, G.T., et al.Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+ -mobilizing activityJ. Biol. Chem.264(3)1608-1615(1989) 2.Guse, A.H.Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR)Curr. Med. Chem.11847-855(2004) 3.Houtkooper, R.H., Cantó, C., Wanders, R.J., et al.The secret life of NAD+: An old metabolite controlling new metabolic signaling pathwaysEndocr. Rev.31(2)194-223(2010) 4.Zhong, J., Amina, S., Liang, M., et al.Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in miceFront. Neurosci.10(304)1-14(2016) 5.Nikiforov, A., Kulikova, V., and Ziegler, M.The human NAD metabolome: Functions, metabolism and compartmentalizationCrit. Rev. Biochem. Mol. Biol.50(4)284-297(2015) 6.Houtkooper, R.H., Cantó, C., Wanders, R.J., et al.The secret life of NAD+: An old metabolite controlling new metabolic signaling pathwaysEndocr. Rev.31(2)194-223(2010) 7.Gul, R., Park, D.-R., Shawl, A.I., et al.Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) mediate Ca2+ signaling in cardiac hypertrophy induced by β-adrenergic stimulationPLoS One11(3)e0149125(2016) 8.Lee, H.C.Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilizationJ. Biol. Chem.287(38)31633-31640(2012) 9.Gul, R., Park, D.-R., Shawl, A.I., et al.Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) mediate Ca2+ signaling in cardiac hypertrophy induced by β-adrenergic stimulationPLoS One11(3)e0149125(2016)

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