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  • AT-130
AT-130的可视化放大

AT-130

An antiviral agent

原价
¥2175-16662
价格
1740-13330
AT-130的二维码

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  • 货号: ajcx32520
  • CAS: 211364-06-6
  • 别名:
  • 分子式: C22H22BrN3O5
  • 分子量: 488.33
  • 纯度: >98%
  • 溶解度: DMSO : 25 mg/mL (51.19 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

AT-130 is an antiviral agent.1,2 It is a non-nucleoside inhibitor of hepatitis B virus (HBV) replication in wild-type and rtL180M, rtM204I, and rtL180M + rtL204V lamivudine-resistant strains of HBV (IC50s = 2.4, 1.6, 5.1, and 1.3 ?M, respectively).2 AT-130 inhibits viral DNA synthesis in HBV-infected HepAD38 cells (EC50 = 0.13 ?M) and reduces the amount of encapsidated RNA in HBV-infected HepG2 cells.2,3


1.Perni, R.B., Conway, S.C., Ladner, S.K., et al.Phenylpropenamide derivatives as inhibitors of hepatitis B virus replicationBioorg. Med. Chem. Lett.10(23)2687-2690(2000) 2.Delaney, W.E., IV, Edwards, R., Colledge, D., et al.Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitroAntimicrob. Agents Chemother.46(9)3057-3060(2002) 3.Feld, J.J., Colledge, D., Sozzi, V., et al.The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packagingAntiviral Res.76(2)168-177(2007)

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