AT-130

An antiviral agent

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库存: 现货

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数量
5mg

￥2175.00

1740.00

- +
10mg

￥4100.00

3280.00

- +
25mg

￥6475.00

5180.00

- +
50mg

￥11337.00

9070.00

- +
100mg

￥16662.00

13330.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

AT-130 is an antiviral agent.^1,2 It is a non-nucleoside inhibitor of hepatitis B virus (HBV) replication in wild-type and rtL180M, rtM204I, and rtL180M + rtL204V lamivudine-resistant strains of HBV (IC₅₀s = 2.4, 1.6, 5.1, and 1.3 ?M, respectively).² AT-130 inhibits viral DNA synthesis in HBV-infected HepAD38 cells (EC₅₀ = 0.13 ?M) and reduces the amount of encapsidated RNA in HBV-infected HepG2 cells.^2,3

1.Perni, R.B., Conway, S.C., Ladner, S.K., et al.Phenylpropenamide derivatives as inhibitors of hepatitis B virus replicationBioorg. Med. Chem. Lett.10(23)2687-2690(2000) 2.Delaney, W.E., IV, Edwards, R., Colledge, D., et al.Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitroAntimicrob. Agents Chemother.46(9)3057-3060(2002) 3.Feld, J.J., Colledge, D., Sozzi, V., et al.The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packagingAntiviral Res.76(2)168-177(2007)