DL-Laudanosine 是 Atracurium 和 Cisatracurium 的代谢物，可透过血脑屏障，引起兴奋和癫痫发作。
DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood-brain barrier and may cause excitement and seizure activity[1].
DL-Laudanosine (Laudanosine) appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals and it is reported to cause arousal from anaesthesia in subconvulsive doses[1].
参考文献:
[1]. V Fodale, et al. Laudanosine, an Atracurium and Cisatracurium Metabolite. Eur J Anaesthesiol. 2002 Jul;19(7):466-73.
[2]. D J Chapple, et al. Cardiovascular and Neurological Effects of Laudanosine. Studies in Mice and Rats, and in Conscious and Anaesthetized Dogs. Br J Anaesth. 1987 Feb;59(2):218-25.
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