An endogenous C-terminal NPY fragment
Neuropeptide Y (NPY) (3-36) is a C-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.1 NPY (3-36) is an endogenous peptide produced by cleavage of NPY by dipeptidyl peptidase 4 (DPP-4).2,3 It binds selectively to the NPY receptor Y2 (Ki = 0.41 nM in CHP 234 cells) over the Y1 receptor, where it does not bind at concentrations up to 1 ?M. NPY (3-36) (0.1 nM) increases migration of human umbilical vein endothelial cells (HUVECs) by 80% after 12 hours in an in vitro wound closure assay.4 NPY (3-36) corresponds to residues 3-36 of the human and rat protein sequence.
1.Balasubramaniam, A.Neuropeptide Y family of hormones: Receptor subtypes and antagonistsPeptides18(3)445-457(1997) 2.Grandt, D., Schimiczek, M., Rascher, W., et al.Neuropeptide Y 3-36 is an endogenous ligand selective for Y2 receptorsRegul. Pept.67(1)33-37(1996) 3.Medeiros, M.d.S., and Turner, A.J.Metabolism and functions of neuropeptide YNeurochem. Res.21(9)1125-1132(1996) 4.Ghersi, G., Chen, W.-T., Lee, E.W., et al.Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to woundingPeptides22(3)453-458(2001)
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